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TAK1 regulates hepatic lipid homeostasis through SREBP

Sterol regulatory element-binding proteins (SREBPs) are key transcription factors regulating cholesterol and fatty acid biosynthesis. SREBP activity is tightly regulated to maintain lipid homeostasis, and is modulated upon extracellular stimuli such as growth factors. While the homeostatic SREBP reg...

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Detalles Bibliográficos
Autores principales: Morioka, Sho, Sai, Kazuhito, Omori, Emily, Ikeda, Yuka, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956508/
https://www.ncbi.nlm.nih.gov/pubmed/26973245
http://dx.doi.org/10.1038/onc.2015.453