Cargando…

TAK1 regulates hepatic lipid homeostasis through SREBP

Sterol regulatory element-binding proteins (SREBPs) are key transcription factors regulating cholesterol and fatty acid biosynthesis. SREBP activity is tightly regulated to maintain lipid homeostasis, and is modulated upon extracellular stimuli such as growth factors. While the homeostatic SREBP reg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morioka, Sho, Sai, Kazuhito, Omori, Emily, Ikeda, Yuka, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956508/ https://www.ncbi.nlm.nih.gov/pubmed/26973245 http://dx.doi.org/10.1038/onc.2015.453

Ejemplares similares

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation
por: Morioka, Sho, et al.
Publicado: (2014)

TAK1 Binding Protein 2 Is Essential for Liver Protection from Stressors
por: Ikeda, Yuka, et al.
Publicado: (2014)

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
por: Morioka, Sho, et al.
Publicado: (2009)

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins
por: Mihaly, September R., et al.
Publicado: (2014)

TAK1 regulates resident macrophages by protecting lysosomal integrity
por: Sakamachi, Yosuke, et al.
Publicado: (2017)

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis
por: Kim, Jae-Young, et al.
Publicado: (2009)

The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism
por: Zhan, Xiudan, et al.
Publicado: (2022)

TAK1 regulates Paneth cell integrity partly through blocking necroptosis
por: Simmons, A N, et al.
Publicado: (2016)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms
por: Takaesu, Giichi, et al.
Publicado: (2012)

Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death
por: Omori, Emily, et al.
Publicado: (2011)

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models
por: Sai, Kazuhito, et al.
Publicado: (2023)

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease
por: Tang, Willcyn, et al.
Publicado: (2022)

Correction to: Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson's disease
Publicado: (2023)

Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1–SREBP pathway
por: Zhang, Yanhong, et al.
Publicado: (2022)

Targeting cholesterol homeostasis through inhibiting SREBP-2: An Achilles’ heel for glioblastoma
por: Sun, Yanfei, et al.
Publicado: (2023)

Magma Seawater Inhibits Hepatic Lipid Accumulation through Suppression of Lipogenic Enzymes Regulated by SREBPs in Thioacetamide-Injected Rats
por: Woo, Minji, et al.
Publicado: (2019)

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis
por: Huber, Michael D., et al.
Publicado: (2013)

Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression
por: Xu, Yingying, et al.
Publicado: (2021)

TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis
por: Roy, Anirban, et al.
Publicado: (2020)

Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice
por: Wang, Chun-Mei, et al.
Publicado: (2016)

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
por: Hendrix, Sebastian, et al.
Publicado: (2023)

Inhibition of SREBP Transcriptional Activity by a Boron-Containing Compound Improves Lipid Homeostasis in Diet-Induced Obesity
por: Zhao, Xiaoping, et al.
Publicado: (2014)

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
por: Wang, Siying, et al.
Publicado: (2023)

GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF-1/SREBP-1
por: Yu, Zhi-Yun, et al.
Publicado: (2022)

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
por: Le Martelot, Gwendal, et al.
Publicado: (2009)

SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
por: Geng, Feng, et al.
Publicado: (2023)

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP‐2
por: Li, Yujie, et al.
Publicado: (2017)

GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction
por: Yang, Xiaoli, et al.
Publicado: (2017)

Impact of silencing hepatic SREBP-1 on insulin signaling
por: Jideonwo, Victoria, et al.
Publicado: (2018)

The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
por: Moon, Young-Ah
Publicado: (2017)

Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1
por: Zhou, Jing-ping, et al.
Publicado: (2020)

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair
por: Ogura, Yuji, et al.
Publicado: (2015)

Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter
por: Meng, Ye, et al.
Publicado: (2019)

Carbon dioxide regulates cholesterol levels through SREBP2
por: Bolshette, Nityanand, et al.
Publicado: (2023)

TAK-242 Ameliorates Hepatic Fibrosis by Regulating the Liver-Gut Axis
por: Liu, Sujie, et al.
Publicado: (2022)

Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling
por: Li, Jian, et al.
Publicado: (2018)

Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c
por: Li, Duan, et al.
Publicado: (2017)

Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy
por: Cui, Donghai, et al.
Publicado: (2023)

microRNA‐143‐3p attenuated development of hepatic fibrosis in autoimmune hepatitis through regulation of TAK1 phosphorylation
por: Tu, Hanxiao, et al.
Publicado: (2019)

Signaling Networks Converge on TORC1-SREBP Activity to Promote Endoplasmic Reticulum Homeostasis
por: Sanchez-Alvarez, Miguel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3hh637vki6f1nop1qbntgc338a