Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial

BACKGROUND: The ex vivo challenge assay is a bio-indicator of drug efficacy and was utilized in this randomized, placebo controlled trial as one of the exploratory endpoints. Fresh and cryopreserved tissues were evaluated for human immunodeficiency virus (HIV) infection and pharmacokinetic (PK)/phar...

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Detalles Bibliográficos
Autores principales: Dezzutti, Charlene S., Richardson-Harman, Nicola, Rohan, Lisa C., Marzinke, Mark A., Hoesley, Craig J., Panther, Lori, Johnson, Sherri, Nuttall, Jeremy P., Nel, Annalene, Chen, Beatrice A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
4850
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956805/
https://www.ncbi.nlm.nih.gov/pubmed/27428211
http://dx.doi.org/10.1097/MD.0000000000004174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956805/
https://www.ncbi.nlm.nih.gov/pubmed/27428211
http://dx.doi.org/10.1097/MD.0000000000004174

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