Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin

The first genetic variant of β(2)‐microglobulin (b2M) associated with a familial form of systemic amyloidosis has been recently described. The mutated protein, carrying a substitution of Asp at position 76 with an Asn (D76N b2M), exhibits a strongly enhanced amyloidogenic tendency to aggregate with...

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Detalles Bibliográficos
Autores principales: Leri, Manuela, Bemporad, Francesco, Oropesa‐Nuñez, Reinier, Canale, Claudio, Calamai, Martino, Nosi, Daniele, Ramazzotti, Matteo, Giorgetti, Sofia, Pavone, Francesco S., Bellotti, Vittorio, Stefani, Massimo, Bucciantini, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956941/
https://www.ncbi.nlm.nih.gov/pubmed/26990223
http://dx.doi.org/10.1111/jcmm.12833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956941/
https://www.ncbi.nlm.nih.gov/pubmed/26990223
http://dx.doi.org/10.1111/jcmm.12833

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