miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis

Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We f...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Cong, Gu, Shen, Cao, Honghui, Li, Zutong, Xiang, Zou, Hu, Kebin, Han, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957095/
https://www.ncbi.nlm.nih.gov/pubmed/27444321
http://dx.doi.org/10.1038/srep30122
_version_ 1782444122722795520
author Wang, Cong
Gu, Shen
Cao, Honghui
Li, Zutong
Xiang, Zou
Hu, Kebin
Han, Xiaodong
author_facet Wang, Cong
Gu, Shen
Cao, Honghui
Li, Zutong
Xiang, Zou
Hu, Kebin
Han, Xiaodong
author_sort Wang, Cong
collection PubMed
description Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSC and attenuates bleomycin-induced lung fibrosis by targeting Smad7. Smad7, as an inhibitory smad in the TGF-β1 signaling pathway, was decreased in the myofibroblast differentiation of LR-MSC and up-regulation of Smad7 could inhibit the differentiation process. Our data implicates a potential application of miR-877-3p as a fibrosis suppressor for pulmonary fibrosis therapy and also as a fibrosis marker for predicting prognosis.
format Online
Article
Text
id pubmed-4957095
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-49570952016-07-26 miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis Wang, Cong Gu, Shen Cao, Honghui Li, Zutong Xiang, Zou Hu, Kebin Han, Xiaodong Sci Rep Article Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSC and attenuates bleomycin-induced lung fibrosis by targeting Smad7. Smad7, as an inhibitory smad in the TGF-β1 signaling pathway, was decreased in the myofibroblast differentiation of LR-MSC and up-regulation of Smad7 could inhibit the differentiation process. Our data implicates a potential application of miR-877-3p as a fibrosis suppressor for pulmonary fibrosis therapy and also as a fibrosis marker for predicting prognosis. Nature Publishing Group 2016-07-22 /pmc/articles/PMC4957095/ /pubmed/27444321 http://dx.doi.org/10.1038/srep30122 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Cong
Gu, Shen
Cao, Honghui
Li, Zutong
Xiang, Zou
Hu, Kebin
Han, Xiaodong
miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title_full miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title_fullStr miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title_full_unstemmed miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title_short miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
title_sort mir-877-3p targets smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957095/
https://www.ncbi.nlm.nih.gov/pubmed/27444321
http://dx.doi.org/10.1038/srep30122
work_keys_str_mv AT wangcong mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT gushen mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT caohonghui mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT lizutong mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT xiangzou mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT hukebin mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis
AT hanxiaodong mir8773ptargetssmad7andisassociatedwithmyofibroblastdifferentiationandbleomycininducedlungfibrosis

Ejemplares similares