A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

Amyloid β1-42 (Aβ1-42) plays a central role in Alzheimer’s disease. The link between structure, assembly and neuronal toxicity of this peptide is of major current interest but still poorly defined. Here, we explored this relationship by rationally designing a variant form of Aβ1-42 (vAβ1-42) differi...

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Detalles Bibliográficos
Autores principales: Marshall, Karen E., Vadukul, Devkee M., Dahal, Liza, Theisen, Alina, Fowler, Milena W., Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J., Staras, Kevin, Serpell, Louise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957119/
https://www.ncbi.nlm.nih.gov/pubmed/27443509
http://dx.doi.org/10.1038/srep30182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957119/
https://www.ncbi.nlm.nih.gov/pubmed/27443509
http://dx.doi.org/10.1038/srep30182

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