Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation

Microgravity induces observed bone loss in space flight, and reduced osteogenesis of bone mesenchymal stem cells (BMSCs) partly contributes to this phenomenon. Abnormal regulation or functioning of the actin cytoskeleton induced by microgravity may cause the inhibited osteogenesis of BMSCs, but the...

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Detalles Bibliográficos
Autores principales: Chen, Zhe, Luo, Qing, Lin, Chuanchuan, Kuang, Dongdong, Song, Guanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957213/
https://www.ncbi.nlm.nih.gov/pubmed/27444891
http://dx.doi.org/10.1038/srep30322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957213/
https://www.ncbi.nlm.nih.gov/pubmed/27444891
http://dx.doi.org/10.1038/srep30322

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