Ca(OH)(2)-Catalyzed Condensation of Aldehydes with Methyl ketones in Dilute Aqueous Ethanol: A Comprehensive Access to α,β-Unsaturated Ketones

Cheap, abundant but seldom-employed Ca(OH)(2) was found to be an excellent low-loading (5–10 mol%) catalyst for Claisen-Schmidt condensation of aldehydes with methyl ketones under mild conditions. It was interesting that dilute aqueous ethanol (20 v/v%) was unexpectedly discovered to be the optimal...

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Detalles Bibliográficos
Autores principales: Yu, Lei, Han, Mengting, Luan, Jie, Xu, Lin, Ding, Yuanhua, Xu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957220/
https://www.ncbi.nlm.nih.gov/pubmed/27443482
http://dx.doi.org/10.1038/srep30432
Descripción
Sumario:Cheap, abundant but seldom-employed Ca(OH)(2) was found to be an excellent low-loading (5–10 mol%) catalyst for Claisen-Schmidt condensation of aldehydes with methyl ketones under mild conditions. It was interesting that dilute aqueous ethanol (20 v/v%) was unexpectedly discovered to be the optimal solvent. The reaction was scalable at least to 100 mmol and calcium could be precipitated by CO(2) and removed by filtration. Evaporation of solvent directly afforded the product in the excellent 96% yield with high purity, as confirmed by its (1)H NMR spectrum.

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