SUMOylation of Rb enhances its binding with CDK2 and phosphorylation at early G1 phase

Retinoblastoma protein (Rb) is a prototypical tumor suppressor that is vital to the negative regulation of the cell cycle and tumor progression. Hypo-phosphorylated Rb is associated with G0/G1 arrest by suppressing E2F transcription factor activity, whereas Rb hyper-phosphorylation allows E2F releas...

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Detalles Bibliográficos
Autores principales: Meng, Fengxi, Qian, Jiang, Yue, Han, Li, Xiaofeng, Xue, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957593/
https://www.ncbi.nlm.nih.gov/pubmed/27163259
http://dx.doi.org/10.1080/15384101.2016.1182267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957593/
https://www.ncbi.nlm.nih.gov/pubmed/27163259
http://dx.doi.org/10.1080/15384101.2016.1182267

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