EGFR C797S mutation mediates resistance to third-generation inhibitors in T790M-positive non-small cell lung cancer

T790M mutation is the most common mechanism for resistance to first- and second-generation tyrosine kinase inhibitors (TKI) for epidermal growth factor receptor (EGFR). Several third-generation EGFR mutant selective TKIs are being explored to conquer this resistance. AZD9291 (osimertinib, tagrisso)...

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Detalles Bibliográficos
Autores principales: Wang, Shuhang, Tsui, Stella T., Liu, Christina, Song, Yongping, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957905/
https://www.ncbi.nlm.nih.gov/pubmed/27448564
http://dx.doi.org/10.1186/s13045-016-0290-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957905/
https://www.ncbi.nlm.nih.gov/pubmed/27448564
http://dx.doi.org/10.1186/s13045-016-0290-1

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