Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

Missense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for cancer therapy are largely unknown. Here we report that 72% of cancer-associated ATM mutations are missense mutations that are enriched aroun...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Kenta, Wang, Jiguang, Sprinzen, Lisa, Xu, Jun, Haddock, Christopher J, Li, Chen, Lee, Brian J, Loredan, Denis G, Jiang, Wenxia, Vindigni, Alessandro, Wang, Dong, Rabadan, Raul, Zha, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957979/
https://www.ncbi.nlm.nih.gov/pubmed/27304073
http://dx.doi.org/10.7554/eLife.14709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957979/
https://www.ncbi.nlm.nih.gov/pubmed/27304073
http://dx.doi.org/10.7554/eLife.14709

Ejemplares similares