Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival

Ehrlichia chaffeensis preferentially targets mononuclear phagocytes and survives through a strategy of subverting innate immune defenses, but the mechanisms are unknown. We have shown E. chaffeensis type 1 secreted tandem repeat protein (TRP) effectors are involved in diverse molecular pathogen-host...

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Detalles Bibliográficos
Autores principales: Lina, Taslima T., Dunphy, Paige S., Luo, Tian, McBride, Jere W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958247/
https://www.ncbi.nlm.nih.gov/pubmed/27381289
http://dx.doi.org/10.1128/mBio.00672-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958247/
https://www.ncbi.nlm.nih.gov/pubmed/27381289
http://dx.doi.org/10.1128/mBio.00672-16

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