Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease and obesity. THM1 (also termed TTC21B or IFT139) enc...

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Detalles Bibliográficos
Autores principales: Jacobs, Damon T., Silva, Luciane M., Allard, Bailey A., Schonfeld, Michael P., Chatterjee, Anindita, Talbott, George C., Beier, David R., Tran, Pamela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958314/
https://www.ncbi.nlm.nih.gov/pubmed/27482817
http://dx.doi.org/10.1242/dmm.025791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958314/
https://www.ncbi.nlm.nih.gov/pubmed/27482817
http://dx.doi.org/10.1242/dmm.025791

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