Effect of methotrexate exposure at middle gestation on the inner plate of the ocular cup and lens in the rat fetus

Pregnant rats were treated intraperitoneally with a single dose of methotrexate (MTX) 90 mg/kg on gestation day (GD) 13, and fetal eyeballs were examined time-dependently from GD 13.5 to 15.5. Throughout the experimental period, the inner plate of the ocular cup in the MTX group was significantly th...

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Detalles Bibliográficos
Autores principales: Zu, Cheng Zhe, Kuroki, Masato, Hirako, Ayano, Takeuchi, Takashi, Furukawa, Satoshi, Sugiyama, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958615/
https://www.ncbi.nlm.nih.gov/pubmed/27559242
http://dx.doi.org/10.1293/tox.2016-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958615/
https://www.ncbi.nlm.nih.gov/pubmed/27559242
http://dx.doi.org/10.1293/tox.2016-0014

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