Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice

Down-regulation of insulin/insulin-like growth factor signaling (IIS) can increase lifespan in C. elegans, Drosophila and mice. In C. elegans, reduced IIS results in down-regulation of translation, which itself can extend lifespan. However, the effect of reduced IIS on translation has yet to be dete...

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Detalles Bibliográficos
Autores principales: Essers, Paul, Tain, Luke S., Nespital, Tobias, Goncalves, Joana, Froehlich, Jenny, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959029/
https://www.ncbi.nlm.nih.gov/pubmed/27452396
http://dx.doi.org/10.1038/srep30290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959029/
https://www.ncbi.nlm.nih.gov/pubmed/27452396
http://dx.doi.org/10.1038/srep30290

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