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Approximate parameter inference in systems biology using gradient matching: a comparative evaluation

BACKGROUND: A challenging problem in current systems biology is that of parameter inference in biological pathways expressed as coupled ordinary differential equations (ODEs). Conventional methods that repeatedly numerically solve the ODEs have large associated computational costs. Aimed at reducing...

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Detalles Bibliográficos
Autores principales: Macdonald, Benn, Niu, Mu, Rogers, Simon, Filippone, Maurizio, Husmeier, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959362/
https://www.ncbi.nlm.nih.gov/pubmed/27454253
http://dx.doi.org/10.1186/s12938-016-0186-x