Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (I(Kr)). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell pat...

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Detalles Bibliográficos
Autores principales: Zhang, Yihong, Colenso, Charlotte K., El Harchi, Aziza, Cheng, Hongwei, Witchel, Harry J., Dempsey, Chris E., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959829/
https://www.ncbi.nlm.nih.gov/pubmed/27256139
http://dx.doi.org/10.1016/j.bcp.2016.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959829/
https://www.ncbi.nlm.nih.gov/pubmed/27256139
http://dx.doi.org/10.1016/j.bcp.2016.05.013

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