A Novel Association of Neuropilin-1 and MUC1 in Pancreatic Ductal Adenocarcinoma: Role in Induction of VEGF Signaling and Angiogenesis

We report that MUC1, a transmembrane glycoprotein that is overexpressed in >80% of pancreatic ductal adenocarcinoma (PDA) induced a pro-angiogenic tumor microenvironment by increasing the levels of neuropilin-1 (NRP1, a co-receptor of VEGF) and its ligand, VEGF. Expression of tumor-associated MUC...

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Detalles Bibliográficos
Autores principales: Zhou, Ru, Curry, Jennifer M, Roy, Lopamudra Das, Grover, Priyanka, Haider, Jamil, Moore, Laura J., Wu, Shu-ta, Kamesh, Anishaa, Yazdanifar, Mahboubeh, Ahrens, William A., Leung, TinChung, Mukherjee, Pinku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960005/
https://www.ncbi.nlm.nih.gov/pubmed/26804176
http://dx.doi.org/10.1038/onc.2015.516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960005/
https://www.ncbi.nlm.nih.gov/pubmed/26804176
http://dx.doi.org/10.1038/onc.2015.516

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