Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists

The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 are involved in a large number of physiological processes including HIV-1 infectivity, inflammation, tumorigenesis, stem cell migration, and autoimmune diseases. While previous efforts have identified a number of CXCR4 antagonists, there ha...

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Detalles Bibliográficos
Autores principales: Mishra, Rama K., Shum, Andrew K., Platanias, Leonidas C., Miller, Richard J., Schiltz, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960487/
https://www.ncbi.nlm.nih.gov/pubmed/27456816
http://dx.doi.org/10.1038/srep30155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960487/
https://www.ncbi.nlm.nih.gov/pubmed/27456816
http://dx.doi.org/10.1038/srep30155

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