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Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists

The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 are involved in a large number of physiological processes including HIV-1 infectivity, inflammation, tumorigenesis, stem cell migration, and autoimmune diseases. While previous efforts have identified a number of CXCR4 antagonists, there ha...

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Detalles Bibliográficos
Autores principales:	Mishra, Rama K., Shum, Andrew K., Platanias, Leonidas C., Miller, Richard J., Schiltz, Gary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960487/ https://www.ncbi.nlm.nih.gov/pubmed/27456816 http://dx.doi.org/10.1038/srep30155

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