NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes

Mutations in mouse and human Nfe2, Fli1 and Runx1 cause thrombocytopenia. We applied genome-wide chromatin dynamics and ChIP-seq to determine these transcription factors’ (TFs) activities in terminal megakaryocyte (MK) maturation. Enhancers with H3K4me2-marked nucleosome pairs were most enriched for...

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Detalles Bibliográficos
Autores principales: Zang, Chongzhi, Luyten, Annouck, Chen, Justina, Liu, X. Shirley, Shivdasani, Ramesh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960521/
https://www.ncbi.nlm.nih.gov/pubmed/27457419
http://dx.doi.org/10.1038/srep30255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960521/
https://www.ncbi.nlm.nih.gov/pubmed/27457419
http://dx.doi.org/10.1038/srep30255

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