Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

Sirtuin 6 (Sirt6), a chromatin associated class III deacetylase, controls whole-body energy homeostasis and has a critical role in glucose-stimulated insulin secretion (GSIS) in pancreatic β cells. However, its underlying molecular mechanism remains poorly understood. To gain further insights, we st...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Mi-Young, Wang, Jie, Ka, Sun-O, Bae, Eun Ju, Park, Byung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960548/
https://www.ncbi.nlm.nih.gov/pubmed/27457971
http://dx.doi.org/10.1038/srep30321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960548/
https://www.ncbi.nlm.nih.gov/pubmed/27457971
http://dx.doi.org/10.1038/srep30321

Ejemplares similares