Structure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity

Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present stu...

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Detalles Bibliográficos
Autores principales: Inokoshi, Junji, Koyama, Nobuhiro, Miyake, Midori, Shimizu, Yuji, Tomoda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960549/
https://www.ncbi.nlm.nih.gov/pubmed/27457620
http://dx.doi.org/10.1038/srep30375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960549/
https://www.ncbi.nlm.nih.gov/pubmed/27457620
http://dx.doi.org/10.1038/srep30375

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