Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation

Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved bioactive compounds to prime MSC. We identified tetrandrine as a potential hit th...

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Detalles Bibliográficos
Autores principales: Yang, Zijiang, Concannon, John, Ng, Kelvin S., Seyb, Kathleen, Mortensen, Luke J., Ranganath, Sudhir, Gu, Fangqi, Levy, Oren, Tong, Zhixiang, Martyn, Keir, Zhao, Weian, Lin, Charles P., Glicksman, Marcie A., Karp, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960598/
https://www.ncbi.nlm.nih.gov/pubmed/27457881
http://dx.doi.org/10.1038/srep30263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960598/
https://www.ncbi.nlm.nih.gov/pubmed/27457881
http://dx.doi.org/10.1038/srep30263

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