Changing Polygenic Penetrance on Phenotypes in the 20(th) Century Among Adults in the US Population

This study evaluates changes in genetic penetrance—defined as the association between an additive polygenic score and its associated phenotype—across birth cohorts. Situating our analysis within recent historical trends in the U.S., we show that, while height and BMI show increasing genotypic penetr...

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Detalles Bibliográficos
Autores principales: Conley, Dalton, Laidley, Thomas M., Boardman, Jason D., Domingue, Benjamin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960614/
https://www.ncbi.nlm.nih.gov/pubmed/27456657
http://dx.doi.org/10.1038/srep30348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960614/
https://www.ncbi.nlm.nih.gov/pubmed/27456657
http://dx.doi.org/10.1038/srep30348

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