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Changing Polygenic Penetrance on Phenotypes in the 20(th) Century Among Adults in the US Population
This study evaluates changes in genetic penetrance—defined as the association between an additive polygenic score and its associated phenotype—across birth cohorts. Situating our analysis within recent historical trends in the U.S., we show that, while height and BMI show increasing genotypic penetr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960614/ https://www.ncbi.nlm.nih.gov/pubmed/27456657 http://dx.doi.org/10.1038/srep30348 |