Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity

Although RNA interference may become a novel therapeutic approach for cancer treatment, target-site accumulation of siRNA to achieve therapeutic dosage will be a major problem. Microneedle represents a better way to deliver siRNAs and we have evaluated for the first time the capability of a silicon...

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Detalles Bibliográficos
Autores principales: Tang, Tao, Deng, Yan, Chen, Jiao, Zhao, Yi, Yue, Ruifeng, Choy, Kwong Wai, Wang, Chi Chiu, Du, Quan, Xu, Yan, Han, Linxiao, Chung, Tony Kwok Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960650/
https://www.ncbi.nlm.nih.gov/pubmed/27457182
http://dx.doi.org/10.1038/srep30430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960650/
https://www.ncbi.nlm.nih.gov/pubmed/27457182
http://dx.doi.org/10.1038/srep30430

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