Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate that there can be marked cellular and phenotypic heterogeneity in a single batch of the human breast adenocarcinoma cell li...

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Detalles Bibliográficos
Autores principales: Kleensang, Andre, Vantangoli, Marguerite M., Odwin-DaCosta, Shelly, Andersen, Melvin E., Boekelheide, Kim, Bouhifd, Mounir, Fornace, Albert J., Li, Heng-Hong, Livi, Carolina B., Madnick, Samantha, Maertens, Alexandra, Rosenberg, Michael, Yager, James D., Zhaog, Liang, Hartung, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960662/
https://www.ncbi.nlm.nih.gov/pubmed/27456714
http://dx.doi.org/10.1038/srep28994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960662/
https://www.ncbi.nlm.nih.gov/pubmed/27456714
http://dx.doi.org/10.1038/srep28994

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