3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA

BACKGROUND: We evaluated the effects of 3-O-methyldopa (3-OMD), a metabolite of l-DOPA which is formed by catechol-O-methyltransferase (COMT), on the uptake, metabolism, and neuroprotective effects of l-DOPA in striatal astrocytes. We examined changes in the numbers of dopaminergic neurons after tre...

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Detalles Bibliográficos
Autores principales: Asanuma, Masato, Miyazaki, Ikuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960704/
https://www.ncbi.nlm.nih.gov/pubmed/27456338
http://dx.doi.org/10.1186/s12868-016-0289-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960704/
https://www.ncbi.nlm.nih.gov/pubmed/27456338
http://dx.doi.org/10.1186/s12868-016-0289-0

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