Crx(Rdy) Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis

PURPOSE: Mutations in the retinal transcription factor cone-rod homeobox (CRX) gene result in severe dominant retinopathies. A large animal model, the Rdy cat, carrying a spontaneous frameshift mutation in Crx, was reported previously. The present study aimed to further understand pathogenesis in th...

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Detalles Bibliográficos
Autores principales: Occelli, Laurence M., Tran, Nicholas M., Narfström, Kristina, Chen, Shiming, Petersen-Jones, Simon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960999/
https://www.ncbi.nlm.nih.gov/pubmed/27427859
http://dx.doi.org/10.1167/iovs.16-19444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960999/
https://www.ncbi.nlm.nih.gov/pubmed/27427859
http://dx.doi.org/10.1167/iovs.16-19444

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