Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

In this tutorial, we introduce basic concepts in dynamical systems analysis, such as phase‐planes, stability, and bifurcation theory, useful for dissecting the behavior of complex and nonlinear models. A precursor‐pool model with positive feedback is used to demonstrate the power of mathematical ana...

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Detalles Bibliográficos
Autores principales: Bakshi, S, de Lange, EC, van der Graaf, PH, Danhof, M, Peletier, LA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961077/
https://www.ncbi.nlm.nih.gov/pubmed/27405001
http://dx.doi.org/10.1002/psp4.12098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961077/
https://www.ncbi.nlm.nih.gov/pubmed/27405001
http://dx.doi.org/10.1002/psp4.12098

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