Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6

In this study, we present efavirenz physiologically based pharmacokinetic (PBPK) model development as an example of our best practice approach that uses a stepwise approach to verify the different components of the model. First, a PBPK model for efavirenz incorporating in vitro and clinical pharmaco...

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Detalles Bibliográficos
Autores principales: Ke, A, Barter, Z, Rowland‐Yeo, K, Almond, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961080/
https://www.ncbi.nlm.nih.gov/pubmed/27435752
http://dx.doi.org/10.1002/psp4.12088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961080/
https://www.ncbi.nlm.nih.gov/pubmed/27435752
http://dx.doi.org/10.1002/psp4.12088

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