Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

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Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic transmission, is a typical case of a human protein that necessitates mammalian systems to obtain functional expression. We d...

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Detalles Bibliográficos
Autores principales: Goldenzweig, Adi, Goldsmith, Moshe, Hill, Shannon E., Gertman, Or, Laurino, Paola, Ashani, Yacov, Dym, Orly, Unger, Tamar, Albeck, Shira, Prilusky, Jaime, Lieberman, Raquel L., Aharoni, Amir, Silman, Israel, Sussman, Joel L., Tawfik, Dan S., Fleishman, Sarel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961223/
https://www.ncbi.nlm.nih.gov/pubmed/27425410
http://dx.doi.org/10.1016/j.molcel.2016.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961223/
https://www.ncbi.nlm.nih.gov/pubmed/27425410
http://dx.doi.org/10.1016/j.molcel.2016.06.012

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