A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease. We report the development of a novel irreversible inhibitor of furin (QUB-F1) consisting of a diphenyl phosphonate ele...

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Detalles Bibliográficos
Autores principales: Ferguson, Timothy E. G., Reihill, James A., Walker, Brian, Hamilton, Robert A., Martin, S. Lorraine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961418/
https://www.ncbi.nlm.nih.gov/pubmed/27459298
http://dx.doi.org/10.1371/journal.pone.0159868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961418/
https://www.ncbi.nlm.nih.gov/pubmed/27459298
http://dx.doi.org/10.1371/journal.pone.0159868

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