Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation

G-protein coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R. Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961583/
https://www.ncbi.nlm.nih.gov/pubmed/27409812
http://dx.doi.org/10.1038/nature18636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961583/
https://www.ncbi.nlm.nih.gov/pubmed/27409812
http://dx.doi.org/10.1038/nature18636

Ejemplares similares