Crystal structure of mammalian acid sphingomyelinase

Acid sphingomyelinase (ASMase, ASM, SMPD1) converts sphingomyelin into ceramide, modulating membrane properties and signal transduction. Inactivating mutations in ASMase cause Niemann–Pick disease, and its inhibition is also beneficial in models of depression and cancer. To gain a better understandi...

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Detalles Bibliográficos
Autores principales: Gorelik, Alexei, Illes, Katalin, Heinz, Leonhard X., Superti-Furga, Giulio, Nagar, Bhushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961792/
https://www.ncbi.nlm.nih.gov/pubmed/27435900
http://dx.doi.org/10.1038/ncomms12196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961792/
https://www.ncbi.nlm.nih.gov/pubmed/27435900
http://dx.doi.org/10.1038/ncomms12196

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