Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-condition...

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Detalles Bibliográficos
Autores principales: Tung, Li-Wei, Lu, Guan-Ling, Lee, Yen-Hsien, Yu, Lung, Lee, Hsin-Jung, Leishman, Emma, Bradshaw, Heather, Hwang, Ling-Ling, Hung, Ming-Shiu, Mackie, Ken, Zimmer, Andreas, Chiou, Lih-Chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961842/
https://www.ncbi.nlm.nih.gov/pubmed/27448020
http://dx.doi.org/10.1038/ncomms12199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961842/
https://www.ncbi.nlm.nih.gov/pubmed/27448020
http://dx.doi.org/10.1038/ncomms12199

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