Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapm...

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Detalles Bibliográficos
Autores principales: Kasuya, Takeshi, Hori, Shin-ichiro, Watanabe, Ayahisa, Nakajima, Mado, Gahara, Yoshinari, Rokushima, Masatomo, Yanagimoto, Toru, Kugimiya, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961955/
https://www.ncbi.nlm.nih.gov/pubmed/27461380
http://dx.doi.org/10.1038/srep30377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961955/
https://www.ncbi.nlm.nih.gov/pubmed/27461380
http://dx.doi.org/10.1038/srep30377

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