Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor

There remains a significant need for development of effective small molecules that can inhibit cytokine-mediated inflammation. Phosphoinositide 3 kinase (PI3K) is a direct upstream activator of AKT, and plays a critical role in multiple cell signaling pathways, cell cycle progression, and cell growt...

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Detalles Bibliográficos
Autores principales: Way, Emily E., Trevejo-Nunez, Giraldina, Kane, Lawrence P., Steiner, Bart H., Puri, Kamal D., Kolls, Jay K., Chen, Kong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961957/
https://www.ncbi.nlm.nih.gov/pubmed/27461849
http://dx.doi.org/10.1038/srep30384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961957/
https://www.ncbi.nlm.nih.gov/pubmed/27461849
http://dx.doi.org/10.1038/srep30384

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