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Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor

There remains a significant need for development of effective small molecules that can inhibit cytokine-mediated inflammation. Phosphoinositide 3 kinase (PI3K) is a direct upstream activator of AKT, and plays a critical role in multiple cell signaling pathways, cell cycle progression, and cell growt...

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Detalles Bibliográficos
Autores principales:	Way, Emily E., Trevejo-Nunez, Giraldina, Kane, Lawrence P., Steiner, Bart H., Puri, Kamal D., Kolls, Jay K., Chen, Kong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961957/ https://www.ncbi.nlm.nih.gov/pubmed/27461849 http://dx.doi.org/10.1038/srep30384

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