Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients

Hereditary heterozygous mutations in a variety of DNA double-strand break (DSB) repair genes have been associated with increased breast cancer risk. In the Finnish population, PALB2 (partner and localizer of BRCA2) represents a major susceptibility gene for female breast cancer, and so far, only one...

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Detalles Bibliográficos
Autores principales: Obermeier, K, Sachsenweger, J, Friedl, T W P, Pospiech, H, Winqvist, R, Wiesmüller, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962030/
https://www.ncbi.nlm.nih.gov/pubmed/26640152
http://dx.doi.org/10.1038/onc.2015.448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962030/
https://www.ncbi.nlm.nih.gov/pubmed/26640152
http://dx.doi.org/10.1038/onc.2015.448

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