Increased dynamics in the 40–57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation

Thrombocytopenia 4 is an inherited autosomal dominant thrombocytopenia, which occurs due to mutations in the human gene for cytochrome c that results in enhanced mitochondrial apoptotic activity. The Gly41Ser mutation was the first to be reported. Here we report stopped-flow kinetic studies of azide...

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Detalles Bibliográficos
Autores principales: Karsisiotis, Andreas Ioannis, Deacon, Oliver M., Wilson, Michael T., Macdonald, Colin, Blumenschein, Tharin M. A., Moore, Geoffrey R., Worrall, Jonathan A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962053/
https://www.ncbi.nlm.nih.gov/pubmed/27461282
http://dx.doi.org/10.1038/srep30447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962053/
https://www.ncbi.nlm.nih.gov/pubmed/27461282
http://dx.doi.org/10.1038/srep30447

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