A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions

STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). The series of molecular rearran...

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Detalles Bibliográficos
Autores principales: Pacheco, Jonathan, Dominguez, Laura, Bohórquez-Hernández, A., Asanov, Alexander, Vaca, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962086/
https://www.ncbi.nlm.nih.gov/pubmed/27459950
http://dx.doi.org/10.1038/srep29634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962086/
https://www.ncbi.nlm.nih.gov/pubmed/27459950
http://dx.doi.org/10.1038/srep29634

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