New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon

BACKGROUND: Disruption of ROBO2 in humans causes vesicoureteral reflux (VUR)/congenital anomalies of the kidney and urinary tract (CAKUT). PiggyBac (PB) is a DNA transposon, and its insertion often reduces—but does not eliminate—gene expression. The Robo2 insertion mutant exhibited non-dilating VUR,...

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Detalles Bibliográficos
Autores principales: Liu, Jialu, Sun, Li, Shen, Qian, Wu, Xiaohui, Xu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962383/
https://www.ncbi.nlm.nih.gov/pubmed/27460642
http://dx.doi.org/10.1186/s12882-016-0308-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962383/
https://www.ncbi.nlm.nih.gov/pubmed/27460642
http://dx.doi.org/10.1186/s12882-016-0308-5

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