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Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq

Accurate characterization of the repertoire of the T-cell receptor (TCR) alpha and beta chains is critical to understanding adaptive immunity. Such characterization has many applications across such fields as vaccine development and response, clone-tracking in cancer, and immunotherapy. Here we pres...

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Detalles Bibliográficos
Autores principales: Redmond, David, Poran, Asaf, Elemento, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962388/
https://www.ncbi.nlm.nih.gov/pubmed/27460926
http://dx.doi.org/10.1186/s13073-016-0335-7