Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

BACKGROUND: The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to induce apoptosis, a timely result given CRC entities harboring such mutations ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Risberg, Karianne, Redalen, Kathrine Røe, Sønstevold, Linda, Bjørnetrø, Tonje, Sølvernes, Janne, Ree, Anne Hansen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962454/
https://www.ncbi.nlm.nih.gov/pubmed/27461218
http://dx.doi.org/10.1186/s12885-016-2600-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962454/
https://www.ncbi.nlm.nih.gov/pubmed/27461218
http://dx.doi.org/10.1186/s12885-016-2600-y

Ejemplares similares