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Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

BACKGROUND: The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to induce apoptosis, a timely result given CRC entities harboring such mutations ar...

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Detalles Bibliográficos
Autores principales:	Risberg, Karianne, Redalen, Kathrine Røe, Sønstevold, Linda, Bjørnetrø, Tonje, Sølvernes, Janne, Ree, Anne Hansen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962454/ https://www.ncbi.nlm.nih.gov/pubmed/27461218 http://dx.doi.org/10.1186/s12885-016-2600-y

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