Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report

• The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL. • IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment. • It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL. • IKZF...

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Autores principales: Vshyukova, Volha, Meleshko, Alexander, Mihal, Natalia, Aleinikova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962816/
https://www.ncbi.nlm.nih.gov/pubmed/27489764
http://dx.doi.org/10.1016/j.lrr.2016.06.005
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author Vshyukova, Volha
Meleshko, Alexander
Mihal, Natalia
Aleinikova, Olga
author_facet Vshyukova, Volha
Meleshko, Alexander
Mihal, Natalia
Aleinikova, Olga
author_sort Vshyukova, Volha
collection PubMed
description • The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL. • IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment. • It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL. • IKZF1 gene alterations may be determined and proved at the genome, expression and protein level. • IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement.
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spelling pubmed-49628162016-08-03 Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report Vshyukova, Volha Meleshko, Alexander Mihal, Natalia Aleinikova, Olga Leuk Res Rep Article • The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL. • IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment. • It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL. • IKZF1 gene alterations may be determined and proved at the genome, expression and protein level. • IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement. Elsevier 2016-06-27 /pmc/articles/PMC4962816/ /pubmed/27489764 http://dx.doi.org/10.1016/j.lrr.2016.06.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Vshyukova, Volha
Meleshko, Alexander
Mihal, Natalia
Aleinikova, Olga
Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title_full Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title_fullStr Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title_full_unstemmed Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title_short Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
title_sort changing of ikzf1 genotype during philadelphia-negative precursor-b acute lymphoblastic leukemia progression: a short clinical report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962816/
https://www.ncbi.nlm.nih.gov/pubmed/27489764
http://dx.doi.org/10.1016/j.lrr.2016.06.005
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