Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-d...

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Detalles Bibliográficos
Autores principales: Panayiotou, Richard, Miralles, Francesc, Pawlowski, Rafal, Diring, Jessica, Flynn, Helen R, Skehel, Mark, Treisman, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963197/
https://www.ncbi.nlm.nih.gov/pubmed/27304076
http://dx.doi.org/10.7554/eLife.15460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963197/
https://www.ncbi.nlm.nih.gov/pubmed/27304076
http://dx.doi.org/10.7554/eLife.15460

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