Different promoter affinities account for specificity in MYC-dependent gene regulation

Enhanced expression of the MYC transcription factor is observed in the majority of tumors. Two seemingly conflicting models have been proposed for its function: one proposes that MYC enhances expression of all genes, while the other model suggests gene-specific regulation. Here, we have explored the...

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Detalles Bibliográficos
Autores principales: Lorenzin, Francesca, Benary, Uwe, Baluapuri, Apoorva, Walz, Susanne, Jung, Lisa Anna, von Eyss, Björn, Kisker, Caroline, Wolf, Jana, Eilers, Martin, Wolf, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963202/
https://www.ncbi.nlm.nih.gov/pubmed/27460974
http://dx.doi.org/10.7554/eLife.15161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963202/
https://www.ncbi.nlm.nih.gov/pubmed/27460974
http://dx.doi.org/10.7554/eLife.15161

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